%PDF-1.3
%
1 0 obj
<>stream
Arbortext Advanced Print Publisher 9.1.531/W Unicode
2020-05-25T01:30:57-07:00
2015-08-18T14:59:07+05:30
application/pdf
REV_ISS_WEB_EMBR_201540891_16-9 1071..1083
PDFlib PLOP 2.0.0p6 (SunOS)/Acrobat Distiller 10.1.1 (Windows); modified using iText 4.2.0 by 1T3XT
uuid:cc2cfa6e-129b-44dc-a6e5-871bcb188806
uuid:5394fab3-7d5b-43c1-a07d-fbd7ff068828
endstream
endobj
59 0 obj
<>stream
h_A òìJTQTAAAT=fݝ}>E]lukچ@40C"t. m,#d$4!':w\
7\\q/.B/x4[;?sn\W~ݹ؞S
Nޱ} %Esdy(؝.X>ajf5c,kdX=)aia%욞Yf%ny13ʛF9jC(A("lG=!X=`E߇e`I?-W-4@ӿi
~$t"I̓7_6|!9L`lϑ,}R=MFQ#34Fީax@hZ Q6WJSJxZYR^Ȟ*<TOʁID^2<<%߄{(-20 g@
endstream
endobj
61 0 obj
<>stream
BOFLLH+AdvPSMP11 qA
AdvPSMP11 K cjbLwnvD!y~y|wmo})xos__HbSdzshz|tsi
endstream
endobj
62 0 obj
<>stream
application/postscript
EMBOR_40891_fig1
© EMBO
Uta Mackensen
Adobe Illustrator CC 2014 (Windows)
2015-07-28T19:23:29+05:30
2015-07-28T19:23:29+05:30
2015-07-28T19:23:29+05:30
256
204
JPEG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xmp.did:9ba6e2b6-4760-ee49-a62e-2f9f9eb9cdef
xmp.iid:9ba6e2b6-4760-ee49-a62e-2f9f9eb9cdef
uuid:ECF26095F26111DFBCDEB911BA5E18E1
proof:pdf
xmp.iid:905178a7-b2a6-ef48-b490-b54aa2da0356
xmp.did:905178a7-b2a6-ef48-b490-b54aa2da0356
uuid:ECF26095F26111DFBCDEB911BA5E18E1
proof:pdf
saved
xmp.iid:FC7F1174072068118083BE73890AE059
2012-08-07T20:21:44+02:00
Adobe Illustrator CS5
/
saved
xmp.iid:9ba6e2b6-4760-ee49-a62e-2f9f9eb9cdef
2015-07-28T19:23:29+05:30
Adobe Illustrator CC 2014 (Windows)
/
converted
from application/postscript to application/vnd.adobe.illustrator
EMBO Graphics figure; EMBO illustration
Mackensen, Uta
Heidelberg
Baden-Wuerttemberg
Germany
2006-01-24
True
www.embo.org
1
True
False
209.999929
280.000136
Millimeters
HelveticaNeue
Helvetica Neue
Regular
Type 1
001.001
False
HELVETIN.PFB; HELVETIN.pfm
HelveticaNeueLTStd-Bd
Helvetica Neue LT Std
75 Bold
Open Type
Version 2.035;PS 002.000;hotconv 1.0.51;makeotf.lib2.0.18671
False
HelveticaNeueLTStd-Bd.otf
Cyan
Magenta
Yellow
Black
Default Swatch Group
0
Adobe PDF library 11.00
endstream
endobj
56 0 obj
<>stream
h^Uu;6e$Ԍb_RB d"!4$HЈ@,@(j3)2B&Cb+8Xad:?>^{}{oroߚ<xg}s~5a
kXְ5a
kXְ5SMUoSw<`G8tcAކ=Ʋ~iLU}Km): 61r_iԯ7/UnFD&{Eݙ+
Έ7~\|JUuh063u+@#יoo/ m]p|܁˜+Su[uvֿ7NːMp{^@;>6WuNoWo;5q'Ae.x* CƆ>wݩ27^碦M;/UϦM7LrPPEzЏ"/I_71wBg̘^*/N
Ls)Lڠ2X0&M<Js}@\pozGYEHp#:LpM"\xk@